PROSIGNE: Serum Proteomic signature of Hepatic Encephalopathy in cirrhotic patient treated by TIPS.


Coordinator: Christophe Bureau

Background and aims

TIPS (transjugular intra-hepatic porto-systemic shunt) is the most effective treatment to prevent complications of portal hypertension observed in cirrhosis but is also at increased risk of developing Hepatic Encephalopathy (HE). HE is a neuropsychiatric syndrome resulting from acute or chronic liver failure. There is no accurate biomarker for diagnosis of minimal hepatic encephalopathy (MHE) and for the risk of overt hepatic encephalopathy (OHE).
OHE occurs in 30%-45% of patients with cirrhosis and 10%-50% of patients after TIPS.
In this challenging project, using proteomic approaches, we aimed to identify circulating protein biomarkers to refine HE diagnosis in a population of patients with cirrhosis treated with TIPS.